Terumo Syringe 2.5ml Luer Lock Syringe, Pack of 100

Product Information

The mean half-life is greater in obese than in non-obese patients (5.9 versus 2.3 hours). This is due to an increase of approximately 50% in the volume of distribution corrected for total body weight. The clearance is not significantly different in obese and non-obese patients.

Medical history of alcohol or drug abuseMidazolam should be avoided in patients with a medical history of alcohol or drug abuse. Midazolam is highly lipophilic and distributes extensively. The steady state volume of distribution following oromucosal administration is estimated to be 5.3 l/kg. Medicinal product interactions following oromucosal administration of midazolam are likely to be similar to those observed after intravenous midazolam rather than oral administration.

Metaraminol 0.5 mg/ml, solution for injection is already diluted and ready to use in pre-filled syringes. It should be used without prior dilution. It is extremely uncommon for insulin to be measured in milligrams. Typically, it's measured as 'units' of insulin or by volume (milliliters). Most commonly insulin is described as a concentration (e.g. units/mL).

Metaraminol is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. It has both alpha and beta-adrenergic activity, the former being predominant. Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables midazolam to form the hydrochloride salt with acids. These produce a stable solution suitable for oromucosal administration. Published clinical studies show that oromucosal midazolam was administered to approx 443 children with seizures. Respiratory depression occurs at a rate of up to 5%, although this is a known complication of convulsive seizures as well as being related to midazolam use. One episode of pruritus was possibly attributed to the use of buccal midazolam. For example, you may see 'Vitamin A' available in a variety of forms in'over-the-counter' supplements, including:The full amount of solution should be inserted slowly into the space between the gum and the cheek (buccal cavity).