Molecular Biology of the Cell

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In a Reaction Center, Light Energy Captured by Chlorophyll Creates a Strong Electron Donor from a Weak One Hedgehog Proteins Act Through a Receptor Complex of Patched and Smoothened, Which Oppose Each Other

Three Molecules of ATP and Two Molecules of NADPH Are Consumed for Each CO 2 Molecule That Is Fixed Basal Laminae Are Composed Mainly of Type IV Collagen, Laminin, Nidogen, and a Heparan Sulfate ProteoglycanIn Single-Pass Transmembrane Proteins, a Single Internal ER Signal Sequence Remains in the Lipid Bilayer as a Membrane-spanning α Helix

Combinations of Start-Transfer and Stop-Transfer Signals Determine the Topology of Multipass Transmembrane Proteins Nucleic Acid Hybridization Reactions Provide a Sensitive Way of Detecting Specific Nucleotide Sequences Four Familiar Signaling Pathways Combine to Pattern the Wing Disc: Wingless, Hedgehog, Dpp, and Notch By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology.As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. Read more... Comparisons Between the DNAs of Related Organisms Distinguish Conserved and Nonconserved Regions of DNA Sequence

Proteins That Bind to the 5′ and 3′ Untranslated Regions of mRNAs Mediate Negative Translational Control Filament Treadmilling and Dynamic Instability Are Consequences of Nucleotide Hydrolysis by Tubulin and Actin A step-by-step account of the operation of the ribosome whose fine-grained structure has recently been solved: how messenger RNA binds to the ribosome substrate and how the transfer RNA is brought into juxtaposition with it so that the right amino acid residue corresponding to the codon can be attached to the growing polypeptide chain. Not only can the process be spelled out in atomic-level detail, but there is some understanding of how error correction works to ensure high fidelity. Two Proteins That Repress Each Other's Synthesis Determine the Heritable State of Bacteriophage LambdaMicrosurgery and Genetics Reveal the Logic of Developmental Control; Gene Cloning and Sequencing Reveal Its Molecular Mechanisms

Part III presents the principles of the main experimental methods for investigating and analysing cells; here, a new section entitled “Mathematical Analysis of Cell Functions” in Chapter 8 provides an extra dimension in our understanding of cell regulation and function. The original idea of a book such as MBoC belonged exclusively to James Watson. In the early 1970s, he wisely spotted a latent hurdle for his long-time vision of transforming the whole biology field into a molecular science. He recognized that the knowledge of cell biology at the time was almost entirely based on light and electron microscopy investigations, and for students this hardly integrated any new molecular biology. Therefore, Watson believed in the need for a new textbook that would combine these two fields. As Martin Raff recalls, for Watson producing MBoC would be a “very important way of modernising the way cell biology was taught and perhaps even how cell biology was done.” Egg-Polarity, Gap, and Pair-Rule Genes Create a Transient Pattern That Is Remembered by Other GenesThe RecA Protein and its Homologs Enable a DNA Single Strand to Pair with a Homologous Region of DNA Double Helix The Membrane Potential in Animal Cells Depends Mainly on K + Leak Channels and the K + Gradient Across the Plasma Membrane