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It’s been six months since I started taking Zenflore, and I’ve noticed I’m generally more relaxed and less stressed. I fall asleep almost immediately nowadays and I wake up refreshed, energised and positive,’ says Louise. Taking a probiotic didn’t make Louise drowsy the next day and has improved her stress levels helping her sleep better Other research has also looked at the effect of prebiotics – that’s foods and supplements that feed the good bacteria in our bodies – and found that they might also have a beneficial effect on sleep. ‘Prebiotics are important because they feed the good bacteria in our guts and help them grow,’ says Dr Murphy. Financial support: The research leading to these results has received funding from the People Programme of the European Union's Seventh Framework Programme under REA grant agreement no. 607652 (NeuroGut).
From an evolutionary perspective, humans are programmed to be highly sensitive to social exclusion and have developed monitoring systems to detect cues ( 30,31). This is necessary for human survival as social isolation is often a fatal threat ( 32,33). As expected, the CBG induced a social stress effect at baseline across all participants. Social exclusion produced differential neural oscillations in all frequency bands in various areas, such as frontal, temporal, and fusiform cortex. These results were similar to previous EEG and MEG studies, showing modulation of neural oscillations by social exclusion ( 14,15,17,21). Previously reported ACC activations were related to processing of negative emotions and event appraisal due to the social stress/exclusion, and PFC activation was related to emotional regulation ( 13,34–36). Theta band oscillations in ACC and insula were described as a marker of social pain in the context of the CBG and was also found during a cold pressor test and physical pain ( 37,38). The participants reported enlarged subjective distress and decreased mood level during the exclusion condition compared with the inclusion condition, consistent to previous studies ( 12,14,15,17). After the intervention, as expected, all participants reported higher distress level during the exclusion condition compared with the inclusion condition after 4 weeks, regardless of the type of intervention (probiotic, placebo). However, a clinical effect of B. longum 1714™ on reducing stress was not observed—the study was not powered to detect differences in subjective stress. Furthermore, as with other stress paradigms, the repetition of stress may reinforce the feeling of being excluded and consolidated the memory of the stressful event making it difficult to detect differences with small numbers.
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However, in comparison to other neurophysiological studies with the CBG ( 22,23), our study involved repeated exposure to the social stress 4 weeks apart. Indeed, similar changes in theta band activity induced by B. longum 1714™ were observed in the resting-state data (before playing the CBG) of the current study, which correlated with increased vitality. These data suggest that the increase in theta and alpha band power by B. longum 1714™ before the stressor may be to some degree a priming for the stressor and may represent an upregulation of appraisal processes and coping mechanisms in the expectation of being exposed to a similar stressful situation again. Furthermore, lower frontal alpha power has been associated with anxiety ( 39,40). The increased alpha oscillation activity in our study may indicate the inhibition of limbic activity and thereby counter-regulate negative emotions and stress. Taking this argument further, we suggest that in contrast to placebo, B. longum 1714™ reduced participants' stress response and enabled them to manage the increased distress level by upregulating processes appraising stressful events and downregulating negative emotions. Although both placebo and probiotic groups reported higher subjective distress, changes in neural processing of social stress were observed only after B. longum 1714™ consumption and not placebo. In addition, the correlation between changes in subjective distress and neural activities was seen only with B. longum 1714™. Therefore, these data support the notion that B. longum 1714™ may play a role in managing stress responses by modulating the relevant neural processes; B. longum 1714™ affecting individuals' neurophysiology is a novel finding and was previously only reported for behavioral data in animals and humans ( 4–6). In this study, we explored the effect of B. longum 1714™ on brain function in response to social stress in a randomized, double-blinded, placebo-controlled trial, using the neuroimaging method magnetoencephalography (MEG). Social stress was induced by social exclusion/rejection ( 11) through a standardized paradigm, called “Cyberball Game” (CBG) ( 12). According to a recent review summarizing previous neuroimaging studies on the CBG, regions of the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and temporal cortex are involved in neural processing of this type of social stressor ( 13). Indeed, social stress during the CBG is consistently associated with altered neural oscillations in certain brain areas, such as alpha band power in frontal cortex and theta band power in the ACC and insula ( 14–17). OPTIMAL GUT SUPPORT scientifically formulated with the unique Bifidobacterium longum 1714-Serenitas culture plus 8 vitamins and minerals including vitamin B6, vitamin B12, biotin, niacin and thiamine Those who regularly sleep badly will be familiar with the myriad of potential fixes on offer. Exercise might help, as might certain nutrients, teas or foods. Then, of course there is always the option of benzodiazepines such as Xanax and Valium, but their addictive potential has been well documented and doctors constantly advise against taking them.
Prebiotics can be found in many high fibre fruits and vegetables including root vegetables, artichokes, bananas, asparagus, sweet potatoes to name a few, as well as whole grains and legumes. ‘It’s yet another reason to get your five a day.’ B. longum 1714™ has been shown to reduce stress-related behaviors in preclinical studies ( 4,5) and improve stress responses and cognitive function in healthy volunteers ( 6). The current functional neuroimaging study showed that B. longum 1714™ significantly altered neural activities in the resting state and in response to a social stressor in healthy participants after a 4-week intervention. The alteration in the resting brain activity by B. longum 1714™ was associated with the SF36 scale “Energy/Vitality.” In response to the social stress, the changed neural activities occurred only in the probiotic group. These data suggest that B. longum 1714™ may play a role in managing stress responses by modulating the relevant neural processes. This exciting product is a type of supplement that through scientific research has shown that it can influence brain function. The bacteria in our gut can beneficially influence the brain response to everyday stress, can communicate directly with the brain via the central nervous system and are now considered vital to brain health. This link is known as the gut-brain axis. The gut-brain axis PrecisionBiotics® are proud to announce Zenflore®, a natural bacterial strain combined with selected B vitamins to provide support for mind and body through life’s daily challenges. Discovered by PrecisionBiotics® at the world-leading APC Microbiome Institute in Cork, the 1714-Serenitas® Bifidobacterium longum culture belongs to a group of bacteria that can be passed from mother to babies at birth. Combined with specially selected B vitamins, this unique strain works to effectively combat mental fatigue and improve mental performance. Neural activities in different frequency bands during exclusion vs inclusion condition. ( a) Theta frequency band (6 Hz): increased power in the bilateral cerebellum (CBL), right middle and inferior frontal cortex (MFC and IFC), left fusiform cortex ( P = 0.004); decreased power in the left middle frontal and bilateral superior frontal cortex (SFC) ( P = 0.02). ( b) Alpha frequency band (11 Hz): increased power in the bilateral CBL, left fusiform, right inferior occipital cortex ( P = 0.002); decreased power in the right SFC ( P< 0.05). ( c) Beta-1 frequency band (16 Hz): increased power in the bilateral CBL, left MFC, left inferior temporal, right middle and superior temporal cortex, and right parahippocampal ( P = 0.004). ( d) Beta-2 frequency band (21 Hz): increased power in the right CBL, left IFC, right inferior and middle temporal cortex (MTC) ( P = 0.002). ( e) Beta-3 frequency band (26 Hz): increased power in the bilateral CBL, right fusiform, left parahippocampal, left MTC ( P = 0.04). B. longum 1714™ altered resting-state brain activity measured by MEGZenflore, with the unique live 1714-Serenitas® culture and specially selected B vitamins, helps support your mind and body during busy and demanding times. Some of the things that could impact your gut bacteria include, naturally, a high stress lifestyle, a diet high in processed foods and sugar and low in fresh vegetables and fruit – and even taking antibiotics at any point in your life – particularly if you have taken them repeatedly. It is known that the health of our gut has a direct correlation to brain function. ZenfloreⓇ has been specifically formulated to encourage serotonin production in the gut, which elevates our mood and to utilise the stress and fatigue-reducing properties of selected B vitamins. ZenfloreⓇ has undergone rigorous clinical trials and human studies and has also been shown to reduce levels of cortisol, the stress hormone.
However, when you’re stressed, your body may have excess cortisol levels and this can contribute to insomnia. There is something called the ‘cortisol awakening response’ that stimulates the body to wakefulness in response to high cortisol. Zenflore are capsules designed to give support for your mind and body during busy and demanding times. We know that gut health is linked to our moods, thanks to the gut being known as ‘the second brain’ because it is responsible for the production of chemicals essential to our moods. There are thousands of different strains of probiotic supplements all of which have different purposes and the reason you need to read the label of the probiotic you’re choosing. After a few weeks, I started to realise I was getting a much better sleep at night,’ Louise remembers. ‘My brain isn’t giving me the annoying ‘updates and analysis’ of everything that has been going on throughout the day. My boyfriend says that I am less moody and I am actually able to plan ahead without feeling under pressure. Basically, I can breathe again.’
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Eilish from Newcastle comments: “I was a bit sceptical at first, but I felt really good, and my concentration levels were much higher. I had so much more energy.” The existence of bidirectional communication between the gut and brain has long been established. Recently, a body of work has suggested that the commensal gut microbiota plays an important role in modulating the gut-brain axis, possibly through immune, endocrine, and neural system pathways ( 1). This has led to increased interest in modulating the gut microbiota to target central nervous system (CNS) functions and improve human behavior especially in areas such as stress, mood, anxiety, and cognition. Probiotics may represent a safe and effective way of targeting CNS function. Indeed, an abundance of preclinical studies have shown that probiotics acting through the gut-brain axis can affect brain development, function, and behavior ( 2). However, the translation of promising preclinical signals into human subjects with certain probiotic strains has proven challenging ( 3). Therefore, there is a need for more detailed mechanistic insights into the interaction between the gut microbiota and brain function in humans. Brain magnetic fields were measured with a 275-channel whole-head MEG (CTF Omega, Port Coquitlam, Canada). Participants were studied in sitting position. During each session, 5 minutes resting state was recorded before playing the CBG. During the resting state, participants were instructed to move as little as possible and to stay alert while keeping their eyes closed. During the CBG, task instructions were projected onto a screen in front of the participants using a video projector and a mirror system. MEG signals were sampled at a rate of 585.94 Hz with an anti-aliasing filter set to 146.49 Hz. Clinical trials have shown that the 1714-Serenitas® probiotic strain can improve ability to process stress by moderating the brain processes linked to negative emotions.
The findings, which were published in 2016 in the journal Translational Psychiatry found that the men taking the daily probiotic – which contained the strain bifidobacterium longum 1714 (also known as Serenitas 1714) which is the same one that is in the new Zenflore probiotic pill – also reported lower levels of stress and lower levels of the stress hormone cortisol in their saliva than those on placebo. Stress, sleep and the cortisol connection Dentistry is known to be stressful [1] but would it surprise you to learn that 85% of us live every day with the consequences of high-pressure lives and struggle to cope with stress and anxiety? Many of us suffer stress-related symptoms ranging from sleeplessness to tooth grinding – which we may feel are not severe enough for medication, yet negatively impact our lives [2]. Regarding the gut brain axis, the strain bifidobacterium longum 1714 also called 1714 Serenitas– was developed and researched in partnership with the University of Cork’s APC Institute – a world leader in microbiome research – specifically for its effects on stress and the brain (see the research below). If you have difficulty swallowing the capsule, it can be opened and the contents sprinkled over food or mixed with fluids.
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Other convincing studies have shown the same probiotic strain may also have a positive effect on memory. While other strains have been studied looking at their effects on the brain, the company responsible for the research and development on bifidobacterium longum 1714 has taken a pharmacological approach, by rigorously testing it in three phases. Stress is common to all of us at some point, especially in the current climate of the pandemic and all the uncertainty that brings. Recognising the first signs of stress is vital to being able to combat it effectively. Did you know there’s a connection between our brain and our gut? I’ve always wondered how the phrase ‘gut feeling’ worked and now I understand it. Thanks to the explanation of the gut-brain axis, which is the two-way dialogue between our brains and our gut. If you’ve ever said you have a ‘gut feeling’ or ‘have butterflies’ to explain how you’re feeling then this is all linked to the gut-brain axis. I know I have. The connection between our brain and our gut is already part of how we talk about our experiences. For example, a “gut-feeling”, a “gut-wrenching” moment or feeling nervous with “butterflies” in the stomach. We know there is a connection between our brain and our gut. Scientists call this connection the gut-brain axis – the two-way dialogue between the brain and the gut where information flows between the two organs. The gut is often described as the second brain. ZenfloreⓇ has been specifically formulated by PrecisionBioticsⓇ to provide natural support during busy and challenging times.
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